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4,5 When adjustments are made for age, sex, and severity of airflow obstruction, patients with chronic bronchitis experience more exacerbations, have worse respiratory health status, and have higher mortality than do patients without chronic bronchitis, highlighting the need for therapies that might improve symptoms and other clinical outcomes in this subset of patients with COPD

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"Distributions of CYP19, ERα and PGR Allele Frequencies between Fertile and Subfertile Holstein-Friesian Heifers" Kafkas Univ Vet Fak Derg 6:893-898 (2015)