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This causes high oxidative stress, mitochondrial dysfunction, and cell death of the hepatocytes.[ref] As these cells die, inflammatory cascades perpetuate the oxidative stress, leading to bleeding, fibrosis, or possibly liver failure

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[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Tokushige K, Takakura M, Tsuchiya-Matsushita N, Taniai M, Hashimoto E, Shiratori K