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After conducting a meta-analysis of the MR results and applying multiple corrections, the combined OR of glutamate for gastroesophageal reflux disease risk was 1.227 (95% CI: 1.068 ~ 1.411 P = 0.043)

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Biomarker Discovery and Validation Challenges Efforts to identify reliable Parkinson’s biomarkers have produced an impressive shortlist—CSF α-syn seeds, plasma neurofilament light chain (NfL), dopamine-transporter imaging, metabolomic and proteomic panels—yet most fall short when confronted with heterogeneity of stage, phenotype, and assay platform