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Compromised DAO function and histamine intolerance may develop as a result of: Mast cell activation syndrome Gluten intolerance Leaky gut syndrome Gut infections, including Helicobacter Pylori, small intestinal bacterial overgrowth (SIBO), Candida and other fungi overgrowth, and parasites Nutrient deficiencies, including vitamin C and B, zinc, and copper that may lead to DAO dysfunction Genetic mutations, including MTHF, HNMT, SAMe, MAO, and DAO mutations Certain medications, including NSAIDs, antidepressants, immune modulators, antiarrhythmics, antihistamines, and histamine blockers Histamine Intolerance and Women Women are particularly affected by histamine intolerance
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