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Another way of considering the chemical basis of these complementary approaches is to note that in procedure A, we leverage the fact that in solution, the deprotonated terminal perthiolate and perthiolate-like sulfur atoms in polysulfides have nucleophilic chemical properties and thus react with IAM/IAM-TPP

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These interactions include: NSP8 interaction with mitochondrial ribosomal protein s2 (MRPS2), mitochondrial ribosomal protein s5 (MRPS5), mitochondrial ribosomal protein s25 (MRPS25), and mitochondrial ribosomal protein s27 (MRPS27) ribosomal proteins