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Mitochondria are the main producer of reactive oxygen species (ROS) and free oxygen radicals, which include ozone (O 3 ), singlet oxygen ( 1 O 2 ), superoxide radical anion (O 2 •− ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radical (HO • ), which are extremely chemically reactive and can react with virtually all substances in the cell [20]