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Ascorbate-glutathione cycle (AGC) The essential role of ascorbate and glutathione results from their participation in the ascorbate-glutathione cycle (AGC), also known as the Halliwell-Asada-Foyer cycle, after the scientists who identified it (Figure 1)

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73,74 Intriguingly, NAA10 has been recently identified to catalyze the lactylation of K508 on NOP2/Sun RNA methyltransferase 2 (NSUN2), which further enhances its catalyzing activity as an RNA methyltransferase to facilitate the m 5 C of glutamate-cysteine ligase catalytic subunit ( GCLC ) mRNA