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This discrepancy between the current study and other studies could be related to the duration of hyperuricemia
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“Diabetic conditions” – such as hyperglycemia and hyperlipidemia – can lead to the loss of the GLP-1 receptor (GLP-1R) from the cell surface and, thereby, impair GLP-1 signaling, which may underlie the reduced clinical efficacy of GLP-1R activators ( Ex vivo treatment of isolated islets with GHRH agonists may also improve results of islet transplantation in animal models
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