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94 By exploiting the pH difference between the TME (pH ~6.5) and normal tissues (pH ~7.4), pH-responsive nanocarriers can be designed to achieve controlled, tumor-specific drug release

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Because half of the isomers present as a mixture in synthetic α-tocopherol are not usable by the body, synthetic α-tocopherol is less bioavailable than natural α-tocopherol (see Figure 1 )