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For example, frataxin loss from de novo [2Fe-2S] cluster synthesis results in Friedrich’s Ataxia and predisposes cells to DNA damage associated with impaired BER, a process that is initiated by [4Fe-4S] containing DNA glycosylases (Haugen et al., 2010
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Thickness:0.05mm
Therefore, DNMTs fusion technology combined with CRISPR/Cas9 system has the potential to be used to specifically edit human DNA methylation in the future
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