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this reduces the peripheral actions of dopamine (mainly the stimulation of the CTZ in the area postrema and resulting nausea and vomiting) and improves the bioavailability of L-DOPA in the CNS, allowing more L-DOPA to reach the brain, where it can be converted to dopamine to help alleviate the symptoms of Parkinson's disease

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[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Westerblad H., Bruton J.D., Katz A