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therefore, drugs targeting EPHB1, PI3K/AKT, and Bcl-2/Bcl-xL, which are involved in the apoptosis resistance pathway, have been developed 28

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Lithium mediates these effects via reactivating the downregulated WNT/β-catenin pathway in MARK2 mutants, in conjunction with enhancing BDNF expression via counteracting its repressive promoter DNA methylation [145]