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As a lipophilic antioxidant, ubiquinol directly neutralizes lipid radicals, establishing a GPX4-independent defense mechanism against ferroptosis ( 3.1.3.3 The Nrf2/ARE pathway Nrf2 is a master regulator of cell defense systems involved in detoxification, antioxidant defense, and resolving inflammation and fibrosis (Xu et al., 2025)
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