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Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver
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In addition, nicotinamide, the primary NNMT substrate 95,96 , is broken down by Lactobacillus arabinosis into nicotinic acid and ammonia 56
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