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Research has shown that the presence of ERα in this region is closely linked to the maintenance of synaptic plasticity, the ability of synapses to strengthen or weaken over time, which is a fundamental mechanism underlying learning and memory [14]

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We observed a consistent increase in sensitivity, or reduced IC 50 value, for mutant cells treated with doxycycline but not parental OVCAR5 cells, indicating that induction of mutant p53 sensitized cells to APR-246 (Fig

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