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The GLS2 encoded glutaminase was originally characterized as dependent on inorganic phosphate (P i ) for activity and is, therefore, also referred to as phosphate-activated glutaminase, PAG
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Accumulating evidence indicates that sepsis-induced neuroinflammation activates microglia, triggering a pro-inflammatory βcytokine stormβ (TNF-Ξ±, IL-1Ξ², IL-6) that exacerbates mitochondrial dysfunction and ROS burst in hippocampal neurons (Michels et al., 2015
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