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Key Research Applications Metabolic Research: Simultaneous activation of three receptors modulates energy balance through complementary mechanisms not achievable with single-agonist compounds

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This implies sodium channel inhibition, a blockade of voltage-gated sodium channels (VGSCs) leading to a reversible block of action potential propagation [278], and reduced permeability of cell membranes, thereby blocking depolarization and preventing the conduction of the electrical impulse through which pain occurs [279]