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The activation of this receptor triggers a signaling cascade that promotes the synthesis and release of GH

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The peptide's signature is balance, not one-way stimulation: in rat models it counteracts a blocked NO system (L-NAME) and an over-stimulated one (L-arginine) alike, with free-radical formation falling alongside — and angiogenesis is promoted in tendon, ligament and muscle models while opposed in the cornea, where transparency depends on keeping vessels out