aod9604 mechanism of action inhibits lipogenesis AOD-9604 Peptide Therapy High Potency Vitamin B

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Evaluation of: Glycerol production (a marker of lipolysis) 2-deoxyglucose uptake (a marker of insulin signaling) DNA synthesis (a marker of proliferation) What they found: AOD-9604 stimulated lipolysis dose-dependently from 10⁻⁹ M, with a plateau at 10⁻⁷ M Full hGH stimulated lipolysis to a similar maximum, but with different kinetics AOD-9604 did not affect glucose uptake or DNA synthesis at all, whereas hGH inhibited both (the classic “lipotoxic” GH effect) Fragments with different sequence (from the N-terminal part of hGH) had no lipolytic effect Why it matters: This was the first publication of AOD-9604

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Growth hormone fragment pharmacology: The molecule serves as a reference compound for studies separating metabolic from mitogenic GH activities