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Accumulation of the toxic metabolite can then exert untoward effects on key cellular structures and functions (Figure 1)

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Other potential regulators and pathways of ferroptosis, such as miR-137 [38], peroxiredoxin-6 (PRDX6) [39], activating transcription factor 4 (ATF4) [40], heat shock protein beta 1(HSPB1) [41], the mevalonate pathway, and the transsulfuration pathway [42] are emergent players in ferroptosis regulation (Fig