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Potential positive feedback loop involving the pentose phosphate... | Download Scientific Diagram

Further research reveals that PCs, alone or in combination with other phytoalexins, can activate the AMPK/SIRT1/NF-κB pathway and inhibit the miR-34a/SIRT1/p53 axis, thereby mitigating hyperglycemia-induced inflammation, oxidative stress, and apoptosis in retinal cells (Liu et al., 2021) (Figure 9)

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[DOI] [PubMed] [Google Scholar] 16.Li J.-M., Li L.-Y., Qin X., Degrace P., Demizieux L., Limbu S.M., Wang X., Zhang M.-L., Li D.-L., Du Z.-Y