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In the broader population without fusions, early-phase studies are justified to test TRKis as stromal- and immunity-modulating agents in biomarker-enriched cohorts defined by NGF/TrkA or BDNF/TrkB activity (transcriptomic receptor–ligand scores, phospho-Trk IHC, or NGF-MMP-2 axis readouts)
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A blend is also only as stable as its least stable constituent, and these four do not share storage and buffer requirements
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