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‘Some of these problems can also occur if you have a deficiency in vitamin B12 or folate, but do not have anaemia.’ There are many journals on this… 2012 Misdiagnosed vitamin B12 deficiency a challenge to be confronted by use of modern screening markers (….”but its absence does not rule out B12 deficiency and it is not a specific marker as using it solely would miss 84 percent cases

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To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

which may be a consideration for some