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Species Concentration Means of Duration Observation Reference administration Rat 25, 50, 100, 200, gavage 13 weeks 25 mg/kg: decreased relative liver weight NTP (1989) 400 mg/kg (males)
Combination Skin
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Activity was monitored by the formation of a fluorescent product (coumarin) generated by a two-step coupled reaction that involved deacetylation of substrate by SIRT-1 followed by secondary release of the fluorophore
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