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In human oncology, most patients diagnosed with CUP (approximately 85–90%) are classified into the unfavorable subgroup, which is associated with a poor clinical outcome and a median survival ranging from 4 to 9 months (4)

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Vascular superoxide is primarily derived from nicotinamide adenine dineucleotide phosphate (NADPH) oxidase when stimulated by hormones, such as angiotensin II (AT-II), endothelin-1 (ET-1) and urotensin II