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Beyond iron overload, whether iron depletion modulates ferroptosis thresholds by impairing mitochondrial respiratory chain complexes—affecting membrane potential and ROS generation—requires validation using conditional iron transporter knockout, iron chelators, and real-time mitochondrial monitoring (123, 124)
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“I do think we should stick to the two doses at this point, but perhaps it would be acceptable to space the doses farther apart eventually to get more people vaccinated more quickly,” she said
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