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In addition to the rapid epigenetic modulation of glutamatergic function, preclinical studies showed that boosting mitochondrial metabolism of LAC protects against oxidative stress, rapidly ameliorates insulin resistance, and reduces neuroinflammation by decreasing proinflammatory pathways such as NFkB in hippocampal and cortical neurons
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Stereoselective activation of Sm .TRPM PZQ by R-PZQ engaging with a hydrophobic ligand-binding pocket triggers a rapid influx of calcium ions that drives membrane depolarization, sustained muscle contraction, spastic paralysis, and tegument disruption, ultimately leading to parasite death [55,56]
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