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Vitamins and Supplements for Nerve Health | The Foundation for Peripheral Neuropathy

De novo synthesis of GSH from cysteine and glutamic acid involves catalysis by glutamate-cysteine ligase (GCL) to form gamma-glutamyl cysteine (g-GC) and the subsequent addition of glycine to g-GC by glutathione synthase (GS) [2]

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While it appears that cells are quite capable of adapting to high expression levels of GSTP, how cells might adapt to the absence of GSTP would also provide an insight into the importance of this protein