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Further studies have found that in lung fibroblasts, periostin/integrin αVβ3 can promote expression of cell cycle-related molecules, including cyclins, cyclin-dependent kinases (CDKs) and E2F families, and transcription factors (such as B-MYB and FOXM1), which play a vital role in the proliferation of lung fibroblasts (Yoshihara et al., 2020)
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