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Experimental animals typically express complex or simple focal seizures characterized by subtle behavioral changes such as freezing periods, facial automatisms, head tremors, or exaggerated startle responses to audiogenic stimuli (Köhling et al., The Stupp regimen is the standard of care for GBM, consisting of resection followed 6 weeks later by post-surgical ionizing radiotherapy (RT) with concomitant TMZ chemotherapy and maintained by 20 weeks of adjuvant TMZ (Stupp et al., 2005, 2009
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