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In addition to inhibiting DNA replication [32], it can also cause necrosis or apoptosis by activating multiple transduction pathways, including Rad9-Hus1-Rad1-ATR-Chk1 pathway, DNA-Pt-HMGB1 ternary complex and p53 pathway, etc [33, 34]
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Dual-energy X-ray absorptiometry DXA was used to assess appendicular lean mass index (ALMI) as a measure of muscle mass
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