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Phase 3 TRIUMPH-4 Trial (December 2025, topline data): Preliminary topline results from TRIUMPH-4, conducted in 445 patients with obesity and knee osteoarthritis, reported that participants taking retatrutide 12 mg lost an average of 28.7% body weight (71.2 lbs) at 68 weeks
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The rat model does not fully replicate the complexity of human PAD, thereby limiting clinical translation
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