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CalçadaDVianelloDGiampieriESalaCCastellaniGde GraafAet alThe role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach
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Similarly, calorie restriction promotes NAD + to stimulate the Nampt-Sirt1 signaling pathway, which can protect the heart from I/R injury by up-regulating antioxidants and down-regulating pro-apoptotic molecules by activating FoxO
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