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This enzyme is encoded by a single gene in Arabidopsis (At5g43940), and catalyzes the NADH-dependent reduction of GSNO to S -aminoglutathione, which then decomposes to ammonia and free GSH (Sakamoto et al., 2002
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As a result, SASP can propagate widely and contribute to tissue dysfunction, including chronic inflammation, fibrosis, and the progression of neurodegenerative diseases (Nelson et al., 2012)
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