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Additionally, arginine residue at position 143 (Arg143) controls the direction of O 2 − in the active site channel and works with Thr137 to restrict the size of anions that approach the Cu center
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While oral antidiabetics and lipid-lowering agents offer potential therapeutic benefits for vitiligo by modulating oxidative stress and inflammation, their use presents limitations (Schernthaner and Chilton, 2010)
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