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Although ultrasmall particles may penetrate more deeply into tumors, they are also more rapidly eliminated, resulting in diminished intratumoral retention (Tang et al., 2014)

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Stress is associated with the activation of the hypothalamic–pituitary–adrenal (HPA) axis (general adaptation syndrome—defined by Selye), but the modern interpretation is much broader and includes reactions even in cells and organisms with simpler structures (2)