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Recent studies have demonstrated that Abelmoschus manihot extract, marketed as Huangkui Capsule (HKC), attenuates diabetic nephropathy progression by reshaping gut microbiota composition, optimizing metabolic parameters, and suppressing expression of renal pro-inflammatory genes

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Acid keeps the protein away from the pH at which its net charge is lowest and aggregation is most favorable, but it also means the concentrated stock is not at physiological pH and that transferring it into a buffered medium involves a pH transition where local precipitation can occur if it is done abruptly into a small volume