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This process can be also elicited modulating cellular sensitivity through the cystine/glutamate antiporter (system Xc-) suppression, acting on their intracellular concentrations, or reducing the activity of GLS2, the enzyme catalyzing the conversion of glutamine into glutamate [31]
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One hypothesis suggests that estrogen receptor alpha (ERα) and matrix metalloproteinase-14-dependent fibrotic pathways may be affected in lipedema, leading to the remodeling of fibrous septa in adipose tissue 29
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