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To our knowledge, Figure 4 is the first model to interconnect: (1) IL-17A-driven MAPK activation, (2) ERK-dependent inflammasome signaling and pyroptosis, (3) HIF-1–mediated tight junction disruption via PTPN2 suppression, and (4) B cell/IgE amplification of mast cell inflammation, into one coordinated molecular framework
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Data is needed on the glutathione concentration of amphibian epidermis, to compare to levels that impacted growth in the kidney cell model
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