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The correlation between antioxidant capacity and oxidative damage during aging has been reported in several tissues in different species,26,27 however data on changes of oxidative stress markers in plasma and erythrocytes of healthy populations during aging are few and sometimes contradictory.28,29 A study carried out in our laboratory on 80 normal healthy subjects of both genders between the ages of 18 and 85 years, showed that there was a significant decrease in reducing potential of plasma as a function of human age.30 Many factors including dietary polyphenols31 influence the extent of reducing/antioxidant potential plasma
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