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Mitochondrial supplementation, though safe, fails to improve oocyte competence, with studies reporting no significant changes in embryo development or fertilization rates ( Despite accumulating evidence, inconsistencies in findings related to macromolecule and nutrient intake highlight the need for clearer mechanistic insights

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Complementing these targeted analyses, a recent epigenome-wide association study demonstrated sex-specific DNA methylation changes and epigenetic age acceleration, including the differential methylation in both CRY2 and RORA, linking NSW to epigenetic alterations in circadian regulators 33