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The occurrence of arthritis by T cells depends on various factors such as the nature and amount of degraded CII moved to the lymph node (the place where CII is supposed to meet T cells), MHC binding ability, and the nature of antigen-presenting cells (APCs) transport

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and (3) that most, but not all, of the observed effects can be described by a simplified model that involves Zn 2+ binding to a first site with an associated electrostatic modification and mechanical slowing of one of the voltage sensors and Zn 2+ binding to a second, lower-affinity site, which blocks the channel and modifies the opening and closing transitions (Figs