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Perspective: The High-Folate–Low-Vitamin B-12 Interaction Is a Novel Cause of Vitamin B-12 Depletion with a Specific Etiology—A Hypothesis - PMC

Low μM amounts of H 2 O 2 can rapidly oxidize the thiol residues on lipoic acid to SOH and deactivate Odh (Figure 2) (Applegate et al., 2 O 2 generating sulfinic (SO 2 H) and sulfonic acid (SO 3 H) which irreversibly deactivates the enzyme complex

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For lifespan epistasis and tissue-specific RNAi experiments, each combination of candidate gene RNAi and mutant/transgenic strain was measured in three independent experiments, each including: wild type worms fed EV(RNAi) , wild-type worms fed candidate RNAi, mutant worms fed EV(RNAi) , and mutant worms fed candidate RNAi