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Despite this growing body of knowledge, we still lack a full understanding of the genetic and molecular controls that govern how peroxidases and NADPH oxidase function under diverse stress conditions [78,79]
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The phase 2 trial of inclisiran (NCT02963311), 38,214,215,216 an siRNA targeting proprotein convertase subtilisin kexin type 9 (PCSK9), also exhibited potent and durable gene silencing and a reduction in low-density lipoprotein cholesterol (LDL-C) (Fig
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