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18,23,123 The prototypical example of a genetic primary astrocytopathy is Alexander disease, a leukomalacia in which astrocytes express mutant GFAP, although how the expression of this mutant gene translates into severe damage of the white matter remains unknown

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6.4 Context-specific shifts in RES/ROS signaling crosstalk RES/ROS regulation permeates every physiological process/pathway known (metabolism, protein quality control, epigenetics, and transcriptional regulation, and so on)