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Additionally, TNF-α plays an important role in the development of insulin resistance, which occurs when the body’s cells cannot respond to insulin, and the increase in inflammatory cytokines such as TNF-α contributes to this metabolic dysfunction
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Although, when the subjects considered not receiving any benefit from vitamin B12, i.e ., those on vitamin B12 supplementation or who were suffering from renal impairment, were excluded from the study, the results among the population showed an enhancement of approximately 21% reduced risk of CVD [78]
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