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Studies (42, 43) have shown that apigenin has a pro-apoptotic effect in human RA-FLS, and it can induce RA-FLS apoptosis by mediating ROS and oxidative stress activator ERK1/2, and mediate apoptotic cell death by activating the apoptotic effector caspase-3/7
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Key pathways such as c-MET and TGF-β, modulated by factors like MACC1, are central to this process
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