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Compared to Arg-465, Trp-847 appeared to bind more tightly to SAM, exhibiting higher interaction scores for both hydrogen bonds and hydrophobic interactions than Arg-465.The binding site of Trp-847 was located near the methyl group of SAM, and Egt1 possessed a conserved domain characteristic of methyltransferases, thus it might be the site where Egt1 exerted its methyltransferase activity

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[DOI] [Google Scholar] 65.Dellatorre G, Antelo DAP, Bedrikow RB, et al

While results vary depending on lifestyle and training intensity