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Adrenoceptors (ARs) are a well-known heterogenous group of hormone/neurotransmitter GPCRs that are divided into three major types, the α 1 -, α 2 - ( α- ARs) and the β adrenoceptors ( β -ARs) based on their affinities for agonists and antagonists, their coupling to signaling pathways, and their amino acid sequences