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Regarding melanoma persister cell formation, two intertwined hypotheses are at play: (1) preexisting persisters may survive treatment due to certain patterns of gene expression, metabolic activity, signaling pathway activity, or differentiation state, or (2) these pro-survival profiles may be induced by the treatments themselves (Fig

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For gastrointestinal fluids, the gastrointestinal tract produces a complex repertoire of physiological secretions, including gastric acid, bile salts and digestive enzymes, that not only mediate nutrient digestion but also exert potent antimicrobial effects